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Bv bij Oriveda, voor uitstekende kwaliteit medicinale paddestoelextracten. Klik door op de link daar: https://kanker-actueel.nl/ops-korting-oriveda-geeft-25-procent-korting-op-extracten-van-medicinale-paddenstoelen-aan-ops-donateurs-van-kanker-actueel.html

10 januari 2023:

Zie ook diverse artikelen over specifieke champignons die medische effecten laten zien indien gebruikt bij kankerpatiënten of als preventie. De bekendste zijn PSK - Coriolus Versicolor en PSP - Protein-bound polysaccharide K - Krestin, maar ook Lentinan, Beta Glucaan en Maitake Fraction en ook OK-432: https://kanker-actueel.nl/psk-en-psp-studies-stofjes-uit-medicinale-paddestoelen-die-afgelopen-20-jaar-uitgevoerd-zijn-bij-kankerpatienten-bij-elkaar-gezet-opvallend-is-dat-bijna-alle-studies-significant-betere-resultaten-geven-voor-de-psk-enof-psp-groepen-to-chemo.html

10 januari 2023: Bron: 2021 Sep; 12(5): 1691–1704. Published online 2021 Mar 16.

Uit een meta analyse van 17 studies blijkt dat wie dagelijks champignons in zijn voeding gebruikt er minder risico op het krijgen van kanker blijkt te zijn. Het verschil tussen een dagelijkse hoeveelheid van 18 gram per dag vergeleken met 0 gram per dag was maar liefst 47 procent. De vraag is natuurlijk ook welke champignons zijn dan het beste te gebruiken, maar daar geeft deze studie niet echt antwoord op.

Studies kwamen in aanmerking voor deze systematische review als ze voldeden aan de volgende criteria:

1) ze gebruikten een observationele studieopzet (case-control of cohortstudieopzet);
2) de blootstelling van belang was de inname via de voeding van eetbare paddenstoelen;
3) de uitkomst was het optreden van kanker;
4) de auteurs rapporteerden associaties in de vorm van relatieve risico's (RR's), hazard ratio's (HR's) of odds ratio's (OR's) met 95% betrouwbaarheidsintervallen (CI's) voor ≥2 categorieën paddenstoeleninname. We identificeerden 19 publicaties bestaande uit 8 cohort- en 11 case-control studies: 17 publicaties (20, 26–31, 33–36, 41–46) werden geïdentificeerd door te zoeken in PubMed (MEDLINE) en 2 publicaties werden geïdentificeerd door handmatig te zoeken in eerdere systematische reviews (47, 48).
Twee publicaties (44, 45) werden uitgesloten van de meta-analyse omdat de inname van paddenstoelen was behandeld als een continue variabele, niet als afzonderlijke categorieën.
De overige 17 publicaties (20, 26–31, 33–36, 41–43, 46–48) werden opgenomen in de meta-analyse (Table 1). Cross-sectionele studies werden uitgesloten van de huidige meta-analyse.

Omdat dit een meta analyse is heb ik het abstract vertaald als weergave van deze studieresultaten, maar in het volledige studieverslag staan veel grafieken en details van de resultaten.

Abstract:

Champignons zijn rijk aan bioactieve stoffen. De potentiële gezondheidsvoordelen die gepaard gaan met de inname van paddenstoelen hebben recentelijk onderzoeksaandacht gekregen. We hebben daarom een systematische review en meta-analyse uitgevoerd om het verband tussen de inname van paddenstoelen en het risico op kanker op elke locatie te beoordelen.

We hebben MEDLINE, Web of Science en Cochrane Library doorzocht om relevante studies te vinden over de inname van paddenstoelen en kanker gepubliceerd van 1 januari 1966 tot 31 oktober 2020. Observationele studies (n = 17) met RR's, HR's of OK's en 95 % CI's van kankerrisico voor ≥2 categorieën paddenstoeleninname kwamen in aanmerking voor de huidige studie.

Meta-analyses met willekeurige effecten werden uitgevoerd. Hogere paddenstoelenconsumptie was geassocieerd met lager risico op totale kanker (gepoolde RR voor de groepen met de hoogste in vergelijking met de laagste consumptie: 0,66; 95% BI: 0,55, 0,78; n = 17).
Hogere paddenstoelenconsumptie was ook geassocieerd met een lager risico op borstkanker (gepoolde RR voor de hoogste in vergelijking met de laagste consumptiegroepen: 0,65; 95% BI: 0,52, 0,81; n = 10) en niet-borstkanker (gepoolde RR voor de hoogste in vergelijking met de laagste verbruiksgroepen: 0,80; 95% BI: 0,66, 0,97; n = 13).

Toen plaatsspecifieke kankers werden onderzocht, werd alleen bij borstkanker een significant verband met paddenstoelenconsumptie waargenomen; dit kan te wijten zijn aan het kleine aantal onderzoeken dat is uitgevoerd met andere kankers. Er waren aanwijzingen voor een significant niet-lineair dosis-responsverband tussen de consumptie van paddenstoelen en het risico op totale kanker (P-niet-lineariteit = 0,001; n = 7).

Beperkingen waren onder meer het potentieel voor herinnerings- en selectiebias in case-control-ontwerpen, die 11 van de 17 onderzoeken omvatten die in deze meta-analyse zijn opgenomen, en de grote variatie in de aanpassingsfactoren die in de uiteindelijke modellen van elk onderzoek zijn gebruikt.

Het verband tussen een hogere consumptie van paddenstoelen en een lager risico op kanker, met name borstkanker, kan wijzen op een mogelijke beschermende rol voor paddenstoelen in de voeding.

Het volledige studierapport is gratis in te zien. Klik daarvoor op de titel van het abstract.

Meta-Analysis

. 2021 Oct 1;12(5):1691-1704.

doi: 10.1093/advances/nmab015.

Higher Mushroom Consumption Is Associated with Lower Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Djibril M Ba 1, Paddy Ssentongo 1, Robert B Beelman 2, Joshua Muscat 1, Xiang Gao 3, John P Richie 1

Affiliations

PMID: 33724299
PMCID: PMC8483951
DOI: 10.1093/advances/nmab015

Free PMC article

Abstract

Mushrooms are rich in bioactive compounds. The potential health benefits associated with mushroom intake have gained recent research attention. We thus conducted a systematic review and meta-analysis to assess the association between mushroom intake and risk of cancer at any site. We searched MEDLINE, Web of Science, and Cochrane Library to identify relevant studies on mushroom intake and cancer published from 1 January, 1966, up to 31 October, 2020. Observational studies (n = 17) with RRs, HRs, or ORs and 95% CIs of cancer risk for ≥2 categories of mushroom intake were eligible for the present study. Random-effects meta-analyses were conducted. Higher mushroom consumption was associated with lower risk of total cancer (pooled RR for the highest compared with the lowest consumption groups: 0.66; 95% CI: 0.55, 0.78; n = 17). Higher mushroom consumption was also associated with lower risk of breast cancer (pooled RR for the highest compared with the lowest consumption groups: 0.65; 95% CI: 0.52, 0.81; n = 10) and nonbreast cancer (pooled RR for the highest compared with the lowest consumption groups: 0.80; 95% CI: 0.66, 0.97; n = 13). When site-specific cancers were examined, a significant association with mushroom consumption was only observed with breast cancer; this could be due to the small number of studies that were conducted with other cancers. There was evidence of a significant nonlinear dose-response association between mushroom consumption and the risk of total cancer (P-nonlinearity = 0.001; n = 7). Limitations included the potential for recall and selection bias in case-control designs, which comprised 11 out of the 17 studies included in this meta-analysis, and the large variation in the adjustment factors used in the final models from each study. The association between higher mushroom consumption and lower risk of cancer, particularly breast cancer, may indicate a potential protective role for mushrooms in the diet.

Keywords: cancer risk; diet; dose-response; epidemiology; mushroom; observational studies.

Figures

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ACKNOWLEDGEMENTS

We thank Esther Dell at the Penn State College of Medicine Libraries for her systematic review consultation about the database and keyword searches. We also thank Dr. Vernon M Chinchilli for providing helpful feedback. The authors’ responsibilities were as follows—DMB, XG, and JPR: designed the research (project conception, development of the overall research plan, and study oversight); DMB and PS: conducted the systematic review and performed the statistical analysis; DMB: analyzed the data, managed the systematic review and meta-analysis, and wrote the first draft of the manuscript; and all authors: review, editing, and approved the final version of the manuscript.

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Notes

The authors reported no funding received for this study.

Author disclosures: The authors report no conflicts of interest.

XG is an Editorial Board member for Advances in Nutrition but played no role in the Journal's evaluation of this manuscript.

Supplemental Figures 1–4 are available from the “Supplementary data” link in the online posting of the article and from the same link in the online table of contents at https://academic.oup.com/advances/.

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Contributor Information

Djibril M Ba, Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

Paddy Ssentongo, Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

Robert B Beelman, Center for Plant and Mushroom Foods for Health, Department of Food Science, College of Agricultural Sciences, Pennsylvania State University, University Park, PA, USA.

Joshua Muscat, Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

Xiang Gao, Department of Nutritional Sciences, Pennsylvania State University, State College, PA, USA.

John P Richie, Jr, Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA.

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paddenstoelen, preventie, risico op kanker, meta analyse