9 augustus 2019: Met dank aan Peter die me hierop wees.

In The New Yorker is een interessant artikel te lezen over hoe de stamceltransplantatie zich ontwikkelde tot de hedendaage CAR-T celtherapie en andere vormen van immuuntherapie met eigen of donorcellen. Zie ook onder personalised medicin of onder immuuntherapie en vaccins

Het artikel is uiteraard in het Engels, maar via google translation rechtsboven dit artikel ook goed te vertalen:

Annals of Medicine

The Promise and Price of Cellular Therapies

New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?

By 

July 15, 2019

It matters that the first patients were identical twins. Nancy and Barbara Lowry were six years old, dark-eyed and dark-haired, with eyebrow-skimming bangs. Sometime in the spring of 1960, Nancy fell ill. Her blood counts began to fall; her pediatricians noted that she was anemic. A biopsy revealed that she had a condition called aplastic anemia, a form of bone-marrow failure.

The marrow produces blood cells, which need regular replenishing, and Nancy’s was rapidly shutting down. The origins of this illness are often mysterious, but in its typical form the spaces where young blood cells are supposed to be formed gradually fill up with globules of white fat. Barbara, just as mysteriously, was completely healthy.

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In the nineteen-fifties, Thomas had attempted a new kind of therapy, in which he infused a leukemia patient with marrow extracted from the patient’s healthy identical twin. There was fleeting evidence that the donated marrow cells had “engrafted” into the patient’s bones, but the patient had swiftly relapsed. Thomas had tried to refine the transplant protocol on dogs, with some marginal success. Now the Seattle doctors persuaded him to try again in humans. Nancy’s marrow was faltering, but no malignant cells were occupying it. Would the blood stem cells from one twin’s marrow “take” in the other twin?>>>>>>>reed the whole article

stamceltransplantatie, immuuntherapie, CAR-T celtherapie, personalised medicin, prijzen van medicijnen, Siddhartha Mukherjee


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