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13 december 2005: Bron: Medscape en Int J Cancer. Posted online December 8, 2005

Vrouwen die primaire borstkanker hebben overleefd hebben een 25% grotere kans in hun latere leven een andere vorm van kanker te krijgen in vergelijking met de doorsnee bevolking. De cijfers zijn nog dramatischer omdat optredende borstkanker in de andere borst is uitgesloten van dit onderzoek. De kankersoorten die optraden bij de vrouwen (525,527 vrouwen namen deel aan dit zeer grote onderzoek over een periode van 60 jaar - 1943 tot 2000 ) die een andere vorm van kanker kregen waren uiterst wisselend. Van leukemie tot darmkanker en er lijkt aldus de onderzoekers geen verwijzing naar een specifieke kankersoort in te ontdekken. Wat de oorzaak is wordt niet echt over geschreven al staat in dit artikel wel dat de behandelingen als bestraling en chemo mede hieraan zouden kunnen bijdragen. Hieronder een artikel van Medscape over deze alarmerende studie.

Dec. 12, 2005 — Women who were previously diagnosed with breast cancer have a high prevalence of second cancers, according to the results of a study reported in the December 8, 2005, Early View issue of the International Journal of Cancer. "A large number of women survive a diagnosis of breast cancer," write Lene Mellemkjær, MD, from the Institute of Cancer Epidemiology at the Danish Cancer Society in Copenhagen, and colleagues. "Knowledge of their risk of developing a new primary cancer is important not only in relation to potential side effects of their cancer treatment, but also in relation to the possibility of shared etiology with other types of cancer." Using 13 population-based cancer registries in Europe, Canada, Australia, and Singapore, the investigators identified 525,527 women with primary breast cancer and observed them for second primary cancers within the period of 1943 through 2000. Cancer incidence rates of the first primary cancer were used to calculate standardized incidence ratios (SIRs) of second primary cancer. Risk for second primary breast cancer after various types of non–breast cancer was also determined. For all second cancer sites combined, excluding contralateral breast cancer, SIR was 1.25 (95% confidence interval , 1.24 - 1.26), based on 31,399 observed cases after first primary breast cancer. Overall risk increased with increased time elapsed since breast cancer diagnosis and decreased with increased age at breast cancer diagnosis. Many different cancer sites were represented at higher than expected frequency. The excess was larger than 150 cases for stomach (SIR, 1.35), colorectal (SIR, 1.22), lung (SIR, 1.24), soft tissue sarcoma (SIR, 2.25), melanoma (SIR, 1.29), nonmelanoma skin (SIR, 1.58), endometrium (SIR, 1.52), ovary (SIR, 1.48), kidney (SIR, 1.27), thyroid (SIR, 1.62), and leukemia (SIR, 1.52). "Women with a first primary breast cancer had a 25% increase in the risk of developing a new primary nonbreast cancer in comparison with women without cancer," the authors write. "The excess of cancer after a breast cancer diagnosis is likely to be explained by treatment for breast cancer and by shared genetic or environmental risk factors, although the general excess of cancer suggests that there may be additional explanations such as increased surveillance and general cancer susceptibility." Study limitations include possible misclassification of some new primary cancers as metastases, lack of information on treatment, lack of generalizability to women who are currently diagnosed with breast cancer, and lack of long-term follow-up on cases diagnosed after 1990. "The known effects of treatment and common risk factors do not seem to fully explain the excesses," the authors conclude. "Future knowledge about the impact of such factors may add further explanations in addition to potential influences from increased surveillance and general cancer susceptibility." The National Cancer Institute sponsored this study. The International Agency for Research on Cancer helped support one of the authors. Int J Cancer. Posted online December 8, 2005.


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