3 maart 2021: Bron: Journal of the anus, rectum and colon.

Constipatie komt veel voor bij patiënten met de ziekte van Parkinson en die constipatie kan ernstige problemen veroorzaken. Tot aan overlijden aan toe. Uit een dubbelblinde en gerandomiseerde placebo gecontroleerde studie blijkt dat probiotica - melkzuurbacteriën de problemen met constipatie kunnen verlichten en verbeteren.

Het gemiddelde aantal wekelijkse spontane stoelgangen nam toe in de behandelingsgroep met 1,0 - 1,2 keer vanaf de 2 weken dat met de probiotica werd begonnen tot de laatste 2 weken van de studie (baseline, 2,6), en nam af met 0,3 in de placebogroep (baseline, 2.8). Secundaire uitkomsten, waaronder kwaliteit van leven gerelateerd aan constipatie, waren ook gunstig voor de actieve behandeling. Er werden geen ernstige bijwerkingen gezien.

Op de website waar deze studie is gepubliceerd kunt u een PDF downloaden van de studie:

Lewy body constipation

  1. Sakakibara R, Doi H, Fukudo S. Lewy body constipation. J Anus Rectum Colon. 2019;3(1):10-17. 
Ryuji Sakakibara, Hirokazu Doi, Shin Fukudo
Author information

Abstract

We systematically reviewed literature regarding "Lewy body constipation", i.e., constipation due to Lewy body diseases (LBD), with minimal neurologic symptoms. Epidemiology and pathology studies showed that LBD can start with constipation alone, mostly due to neuronal loss and appearance of Lewy bodies in the myenteric plexus. Because LBD significantly increases with age, "Lewy body constipation" may also increase with age. Neuroimaging methods such as metaiodobenzylguanidine (MIBG) scintigraphy and dopamine transporter (DAT) scan provide a way to detect "Lewy body constipation." Key for "Lewy body constipation" includes minimal non-motor features such as REM sleep behavior disorder (night talking). Add-on therapy may be required to ameliorate constipation in patients. Diagnosis is not always easy; therefore, collaboration of gastroenterologists and neurologists is highly recommended to maximize patients' quality of life. In conclusion, "Lewy body constipation" might become a distinct category among geriatric constipation, regarding patients' follow-up and their management.

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Ziekte van Parkinson, constipatie, probiotica, darmflora, melkzuurbacterien


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