26 maart 2009: Bron:

Wie als kind of adolescent regelmatig soja eet of drinkt vermindert daarmee het risico op het krijgen van borstkanker op latere leeftijd. Ook volwassenen die regelmatig soja drinken of eten verminderen het risico op borstkanker. Maar het effect is voor kinderen en pubers groter. Het verschil tussen hoogste inname en laagste inname gaf een verschil in risico van 58%. Aldus een studie naar eetgewoonten onder Aziatische vouwen met borstkanker die in Azie wonen en in Amerika wonen. Bij elke groep waren de resultaten min of meer hetzelfde.

1: Cancer Epidemiol Biomarkers Prev. 2009 Mar 24. [Epub ahead of print]

Childhood Soy Intake and Breast Cancer Risk in Asian American Women.

Clinical Genetics Branch and Epidemiology and Biostatistics Program, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; University of Southern California School of Medicine, Los Angeles, California; Epidemiology Program, University of Hawaii, Honolulu, Hawaii; and Northern California Cancer Center, Fremont, California.

INTRODUCTION: Historically, breast cancer incidence has been substantially higher in the United States than in Asia. When Asian women migrate to the United States, their breast cancer risk increases over several generations and approaches that for U.S. Whites. Thus, modifiable factors, such as diet, may be responsible.

METHODS: In this population-based case-control study of breast cancer among women of Chinese, Japanese, and Filipino descent, ages 20 to 55 years, and living in San Francisco-Oakland (California), Los Angeles (California) and Oahu (Hawaii), we interviewed 597 cases (70% of those eligible) and 966 controls (75%) about adolescent and adult diet and cultural practices. For subjects with mothers living in the United States (39% of participants), we interviewed mothers of 99 cases (43% of eligible) and 156 controls (40%) about the daughter's childhood exposures. Seventy-three percent of study participants were premenopausal at diagnosis.

RESULTS: Comparing highest with lowest tertiles, the multivariate relative risks (95% confidence interval) for childhood, adolescent, and adult soy intake were 0.40 (0.18-0.83; Ptrend = 0.03), 0.80 (0.59-1.08; Ptrend = 0.12), and 0.76 (0.56-1.02; Ptrend = 0.04), respectively. Inverse associations with childhood intake were noted in all three races, all three study sites, and women born in Asia and the United States. Adjustment for measures of westernization attenuated the associations with adolescent and adult soy intake but did not affect the inverse relationship with childhood soy intake.

DISCUSSION: Soy intake during childhood, adolescence, and adult life was associated with decreased breast cancer risk, with the strongest, most consistent effect for childhood intake. Soy may be a hormonally related, early-life exposure that influences breast cancer incidence. (Cancer Epidemiol Biomarkers Prev 2009;18(4):OF1-10).

PMID: 19318430 [PubMed - as supplied by publisher]




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