Aids - HIV en effect van voeding en voedingstoffen: 60 mg. retinol ( 200.000 IE) - vitamine A per dag gegeven aan kinderen besmet met het HIV virus geeft 40 procent minder sterfte gerekend over periodes van drie maanden.

26 april 2005: Bron: Orthomoleculaire Koerier en Nutrition. 2005 Jan;21(1):25-31.

Misschien beetje off topic, maar het resultaat van deze onderstaande studie is zo opmerkelijk dat we die hier toch publiceren. Tenslotte krijgen veel Aids patiënten ook vormen van kanker vaak door inefficiënt immuunsysteem.

In dit gerandomiseerde dubbelblinde onderzoek kregen t.o. 94 kinderen in placebogroep, 87 Oegandese kinderen besmet met het HIV-virus elke dag 60 mg. retinol (= 200.000 IE) = vitamine A toegediend. Van de groep die dit kreeg bleek bij een mediane follow-up van 17,8 maanden de sterfte gerekend in periodes van drie maanden met ca. 40% afgenomen. (95% confidence interval, 0.30 to 0.98; P = 0.044) De sterfte in de Placebogroep t.o.v. Vitamine A groep was resp.: 32,9 % versus 20,6%. Het onderzoek is uitgevoerd door de John Hopkins school for Medicine uit Baltimore en op basis van dit onderzoek krijgen nu massaal kinderen in Oeganda besmet met het HIV-virus vitamine A toegediend.

Effect of periodic vitamin A supplementation on mortality and morbidity of human immunodeficiency virus-infected children in Uganda: A controlled clinical trial.

Semba RD, Ndugwa C, Perry RT, Clark TD, Jackson JB, Melikian G, Tielsch J, Mmiro F.
Department of Ophthalmology Johns Hopkins School of Medicine, Baltimore, MD, USA. rdsemba@jhmi.edu

OBJECTIVE: We investigated whether vitamin A supplementation would decrease mortality and morbidity rates in children infected with the human immunodeficiency virus (HIV). METHODS: We conducted a randomized, double-blind, placebo-controlled clinical trial at Mulago Hospital, a large hospital that serves the urban and semiurban populations of Kampala, Uganda. One hundred eighty-one HIV-infected children were enrolled at 6 mo and randomized to receive vitamin A supplementation, 60 mg retinol equivalent, or placebo every 3 mo from ages 15 to 36 mo. Morbidity was assessed through a 7-d morbidity history every 3 mo, and vital events were measured. Children received daily trimethoprim-sulfamethoxazole prophylactic therapy.

RESULTS: After age 15 mo, children were followed for a median of 17.8 mo (interquartile range = 11.1 to 21.0 mo). The trial was stopped when there was a new policy to implement a program of mass supplementation of vitamin A in the country. Mortality rates among 87 children in the vitamin A group and 94 children in the control group were 20.6% and 32.9%, respectively, yielding a relative risk of 0.54 (95% confidence interval, 0.30 to 0.98; P = 0.044) after adjusting for baseline weight-for-height Z score. Children who received vitamin A had lower modified point prevalences of persistent cough (odds ratio, 0.47; 95% confidence interval, 0.23 to 0.96; P = 0.038) and chronic diarrhea (odds ratio, 0.48; 95% confidence interval, 0.19 to 1.18; P = 0.11) and a shorter duration of ear discharge (P = 0.03). Vitamin A supplementation had no significant effect on modified point prevalences of fever, ear discharge, bloody stools, or hospitalizations.

CONCLUSIONS: Vitamin A supplementation decreases mortality rate in HIV-infected children and should be considered in the care for these children in developing countries.

PMID: 15661475 [PubMed - in process]

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