6 juli 2023: Bron:  2021; 16(9): e0256992. Published online 2021 Sep 2.


De werkzaamheid van cranberrysap en cranberrysuppletie (cranberry = veenbessen) als behandeling bij het voorkomen van urineweginfecties bij daarvoor gevoelige mensen om verschillende redenen blijkt bijzonder goed te zijn. Zo blijkt uit de resultaten van een grote meta-analyse studie. Uit de totale resultaten blijkt op z'n minst een 35 procent minder risico door gebruik van cranberry's - veenbessen op ontstaan van urineweginfecties bij daarvoor gevoelige groepen mensen. 

Deze meta-analyse werd gemaakt over 23 studies met totaal 3979 deelnemers. Uit de analyse blijkt dat de inname van producten op basis van cranberry's de incidentie van urineweginfecties in vatbare populaties aanzienlijk kan verminderen (risicoverhouding (RR) = 0,70; 95% betrouwbaarheidsinterval (BI): 0,59 ~ 0,83; P<0,01).
De onderzoekers identificeerden een relatieve risicoreductie van 32%, 45% en 51% bij vrouwen met recidiverende urineweginfecties (RR = 0,68; 95% BI: 0,56 ~ 0,81), kinderen (RR = 0,55; 95% BI: 0,31 ~ 0,97) en bij patiënten die katheters moesten gebruiken (RR = 0,49; 95% BI: 0,33 ~ 0,73).
Ook werd een relatieve risicoreductie van 35% waargenomen bij mensen die cranberrysap gebruiken in vergelijking met degenen die cranberrycapsules of -tabletten gebruiken in de subgroepanalyse (RR = 0,65; 95% BI: 0,54 ~ 0,77).
Het totale resultaat uit de meta-analyse voor de effecten van cranberry-inname en het verminderde risico op urineweginfecties in gevoelige groepen gaf aan dat de effecten overtuigend waren.

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Concluderend toont deze meta-analyse aan dat suppletie met cranberry's - veenbessen het risico op het ontwikkelen van urineweginfecties bij gevoelige populaties aanzienlijk verminderde. Cranberry kan worden beschouwd als een effectieve aanvullende behandeling voor het voorkomen van urineweginfecties bij gevoelige populaties.

Het volledige studieverslag is gratis in te zien. Klik op de titel van het abstract:

 2021; 16(9): e0256992.
Published online 2021 Sep 2. doi: 10.1371/journal.pone.0256992
PMCID: PMC8412316
PMID: 34473789

Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis

Jia-yue Xia, Conceptualization, Formal analysis, Methodology, Supervision, Validation, Writing – original draft, Writing – review & editing, 1 , 2 Chao Yang, Conceptualization, 1 , 2 Deng-feng Xu, Data curation, Formal analysis, Software, 1 , 2 Hui Xia, Data curation, Formal analysis, Software, Visualization, 1 , 2 Li-gang Yang, Methodology, Visualization, 1 , 2 and Gui-ju Sun, Supervision, Validation, Visualization, Writing – review & editing 1 , 2 ,*
Frank T. Spradley, Editor

Abstract

The efficacy of cranberry (Vaccinium spp.) as adjuvant therapy in preventing urinary tract infections (UTIs) remains controversial. This study aims to update and determine cranberry effects as adjuvant therapy on the recurrence rate of UTIs in susceptible groups. According to PRISMA guidelines, we conducted a literature search in Web of Science, PubMed, Embase, Scopus, and the Cochrane Library from their inception dates to June 2021. We included articles with data on the incidence of UTIs in susceptible populations using cranberry-containing products. We then conducted a trial sequential analysis to control the risk of type I and type II errors. This meta-analysis included 23 trials with 3979 participants. We found that cranberry-based products intake can significantly reduce the incidence of UTIs in susceptible populations (risk ratio (RR) = 0.70; 95% confidence interval(CI): 0.59 ~ 0.83; P<0.01). We identified a relative risk reduction of 32%, 45% and 51% in women with recurrent UTIs (RR = 0.68; 95% CI: 0.56 ~ 0.81), children (RR = 0.55; 95% CI: 0.31 ~ 0.97) and patients using indwelling catheters (RR = 0.49; 95% CI: 0.33 ~ 0.73). Meanwhile, a relative risk reduction of 35% in people who use cranberry juice compared with those who use cranberry capsule or tablet was observed in the subgroup analysis (RR = 0.65; 95% CI: 0.54 ~ 0.77). The TSA result for the effects of cranberry intake and the decreased risk of UTIs in susceptible groups indicated that the effects were conclusive. In conclusion, our meta-analysis demonstrates that cranberry supplementation significantly reduced the risk of developing UTIs in susceptible populations. Cranberry can be considered as adjuvant therapy for preventing UTIs in susceptible populations. However, given the limitations of the included studies in this meta-analysis, the conclusion should be interpreted with caution.

Acknowledgments

We sincerely thank all support from all authors.

Funding Statement

The author(s) received no specific funding for this work.

Data Availability

All relevant data are within the manuscript and its Supporting information files.

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