6 juli 2023: Bron:  2021; 16(9): e0256992. Published online 2021 Sep 2.

De werkzaamheid van cranberrysap en cranberrysuppletie (cranberry = veenbessen) als behandeling bij het voorkomen van urineweginfecties bij daarvoor gevoelige mensen om verschillende redenen blijkt bijzonder goed te zijn. Zo blijkt uit de resultaten van een grote meta-analyse studie. Uit de totale resultaten blijkt op z'n minst een 35 procent minder risico door gebruik van cranberry's - veenbessen op ontstaan van urineweginfecties bij daarvoor gevoelige groepen mensen. 

Deze meta-analyse werd gemaakt over 23 studies met totaal 3979 deelnemers. Uit de analyse blijkt dat de inname van producten op basis van cranberry's de incidentie van urineweginfecties in vatbare populaties aanzienlijk kan verminderen (risicoverhouding (RR) = 0,70; 95% betrouwbaarheidsinterval (BI): 0,59 ~ 0,83; P<0,01).
De onderzoekers identificeerden een relatieve risicoreductie van 32%, 45% en 51% bij vrouwen met recidiverende urineweginfecties (RR = 0,68; 95% BI: 0,56 ~ 0,81), kinderen (RR = 0,55; 95% BI: 0,31 ~ 0,97) en bij patiënten die katheters moesten gebruiken (RR = 0,49; 95% BI: 0,33 ~ 0,73).
Ook werd een relatieve risicoreductie van 35% waargenomen bij mensen die cranberrysap gebruiken in vergelijking met degenen die cranberrycapsules of -tabletten gebruiken in de subgroepanalyse (RR = 0,65; 95% BI: 0,54 ~ 0,77).
Het totale resultaat uit de meta-analyse voor de effecten van cranberry-inname en het verminderde risico op urineweginfecties in gevoelige groepen gaf aan dat de effecten overtuigend waren.

An external file that holds a picture, illustration, etc.
Object name is pone.0256992.g001.jpg

Concluderend toont deze meta-analyse aan dat suppletie met cranberry's - veenbessen het risico op het ontwikkelen van urineweginfecties bij gevoelige populaties aanzienlijk verminderde. Cranberry kan worden beschouwd als een effectieve aanvullende behandeling voor het voorkomen van urineweginfecties bij gevoelige populaties.

Het volledige studieverslag is gratis in te zien. Klik op de titel van het abstract:

 2021; 16(9): e0256992.
Published online 2021 Sep 2. doi: 10.1371/journal.pone.0256992
PMCID: PMC8412316
PMID: 34473789

Consumption of cranberry as adjuvant therapy for urinary tract infections in susceptible populations: A systematic review and meta-analysis with trial sequential analysis

Jia-yue XiaConceptualizationFormal analysisMethodologySupervisionValidationWriting – original draftWriting – review & editing, 1 , 2 Chao YangConceptualization, 1 , 2 Deng-feng XuData curationFormal analysisSoftware, 1 , 2 Hui XiaData curationFormal analysisSoftwareVisualization, 1 , 2 Li-gang YangMethodologyVisualization, 1 , 2 and Gui-ju SunSupervisionValidationVisualizationWriting – review & editing 1 , 2 ,*
Frank T. Spradley, Editor


The efficacy of cranberry (Vaccinium spp.) as adjuvant therapy in preventing urinary tract infections (UTIs) remains controversial. This study aims to update and determine cranberry effects as adjuvant therapy on the recurrence rate of UTIs in susceptible groups. According to PRISMA guidelines, we conducted a literature search in Web of Science, PubMed, Embase, Scopus, and the Cochrane Library from their inception dates to June 2021. We included articles with data on the incidence of UTIs in susceptible populations using cranberry-containing products. We then conducted a trial sequential analysis to control the risk of type I and type II errors. This meta-analysis included 23 trials with 3979 participants. We found that cranberry-based products intake can significantly reduce the incidence of UTIs in susceptible populations (risk ratio (RR) = 0.70; 95% confidence interval(CI): 0.59 ~ 0.83; P<0.01). We identified a relative risk reduction of 32%, 45% and 51% in women with recurrent UTIs (RR = 0.68; 95% CI: 0.56 ~ 0.81), children (RR = 0.55; 95% CI: 0.31 ~ 0.97) and patients using indwelling catheters (RR = 0.49; 95% CI: 0.33 ~ 0.73). Meanwhile, a relative risk reduction of 35% in people who use cranberry juice compared with those who use cranberry capsule or tablet was observed in the subgroup analysis (RR = 0.65; 95% CI: 0.54 ~ 0.77). The TSA result for the effects of cranberry intake and the decreased risk of UTIs in susceptible groups indicated that the effects were conclusive. In conclusion, our meta-analysis demonstrates that cranberry supplementation significantly reduced the risk of developing UTIs in susceptible populations. Cranberry can be considered as adjuvant therapy for preventing UTIs in susceptible populations. However, given the limitations of the included studies in this meta-analysis, the conclusion should be interpreted with caution.


We sincerely thank all support from all authors.

Funding Statement

The author(s) received no specific funding for this work.

Data Availability

All relevant data are within the manuscript and its Supporting information files.


1. Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment optionsNat Rev Microbiol. 2015;13(5):269–84. Epub 2015/04/09. doi: 10.1038/nrmicro3432 . [PMC free article] [PubMed] [CrossRef[]
2. Kumar MS, Das AP. Emerging nanotechnology based strategies for diagnosis and therapeutics of urinary tract infections: A reviewAdv Colloid Interface Sci. 2017;249:53–65. Epub 2017/07/03. doi: 10.1016/j.cis.2017.06.010 . [PubMed] [CrossRef[]
3. Johnson CC. Definitions, classification, and clinical presentation of urinary tract infectionsMed Clin North Am. 1991;75(2):241–52. Epub 1991/03/01. doi: 10.1016/s0025-7125(16)30451-5 . [PubMed] [CrossRef[]
4. Foxman B, Brown P. Epidemiology of urinary tract infections: transmission and risk factors, incidence, and costsInfect Dis Clin North Am. 2003;17(2):227–41. Epub 2003/07/10. doi: 10.1016/s0891-5520(03)00005-9 . [PubMed] [CrossRef[]
5. Guay DR. Cranberry and urinary tract infectionsDrugs. 2009;69(7):775–807. Epub 2009/05/16. doi: 10.2165/00003495-200969070-00002 . [PubMed] [CrossRef[]
6. Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infectionsCochrane Database Syst Rev. 2012;10(10):Cd001321. Epub 2012/10/19. doi: 10.1002/14651858.CD001321.pub5. [PMC free article] [PubMed] [CrossRef[]
7. Pappas E, Schaich KM. Phytochemicals of cranberries and cranberry products: characterization, potential health effects, and processing stabilityCrit Rev Food Sci Nutr. 2009;49(9):741–81. Epub 2010/05/06. doi: 10.1080/10408390802145377 . [PubMed] [CrossRef[]
8. Ermel G, Georgeault S, Inisan C, Besnard M. Inhibition of adhesion of uropathogenic Escherichia coli bacteria to uroepithelial cells by extracts from cranberryJ Med Food. 2012;15(2):126–34. doi: 10.1089/jmf.2010.0312 . [PubMed] [CrossRef[]
9. Sun J, Marais JPJ, Khoo C, LaPlante K, Vejborg RM, Givskov M, et al. Cranberry () oligosaccharides decrease biofilm formation by uropathogenicJ Funct Foods. 2015;17:235–42. doi: 10.1016/j.jff.2015.05.016 . [PMC free article] [PubMed] [CrossRef[]
10. Luís Â, Domingues F, Pereira L. Can Cranberries Contribute to Reduce the Incidence of Urinary Tract Infections? A Systematic Review with Meta-Analysis and Trial Sequential Analysis of Clinical TrialsJ Urol. 2017;198(3):614–21. doi: 10.1016/j.juro.2017.03.078 . [PubMed] [CrossRef[]
11. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statementAnn Intern Med. 2009;151(4). doi: 10.7326/0003-4819-151-4-200908180-00135. [PubMed] [CrossRef[]
12. Higgins JPT, Altman DG, Gøtzsche PC, Jüni P, Moher D, Oxman AD, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trialsBMJ. 2011;343:d5928. doi: 10.1136/bmj.d5928. [PMC free article] [PubMed] [CrossRef[]
13. George BJ, Aban IB. An application of meta-analysis based on DerSimonian and Laird methodJournal of Nuclear Cardiology. 2016;23(4):690–2. doi: 10.1007/s12350-015-0249-6 [PubMed] [CrossRef[]
14. Duval S, Tweedie R. Trim and fill: A simple funnel-plot-based method of testing and adjusting for publication bias in meta-analysisBiometrics. 2000;56(2):455–63. Epub 2000/07/06. doi: 10.1111/j.0006-341x.2000.00455.x . [PubMed] [CrossRef[]
15. Wetterslev J, Jakobsen JC, Gluud C. Trial Sequential Analysis in systematic reviews with meta-analysisBMC Med Res Methodol. 2017;17(1):39. Epub 2017/03/08. doi: 10.1186/s12874-017-0315-7. [PMC free article] [PubMed] [CrossRef[]
16. Stothers L. A randomized trial to evaluate effectiveness and cost effectiveness of naturopathic cranberry products as prophylaxis against urinary tract infection in womenCan J Urol. 2002;9(3):1558–62. . [PubMed[]
17. Caljouw MAA, van den Hout WB, Putter H, Achterberg WP, Cools HJM, Gussekloo J. Effectiveness of cranberry capsules to prevent urinary tract infections in vulnerable older persons: a double-blind randomized placebo-controlled trial in long-term care facilitiesJ Am Geriatr Soc. 2014;62(1):103–10. doi: 10.1111/jgs.12593 . [PMC free article] [PubMed] [CrossRef[]
18. Wing DA, Rumney PJ, Preslicka CW, Chung JH. Daily cranberry juice for the prevention of asymptomatic bacteriuria in pregnancy: a randomized, controlled pilot studyJ Urol. 2008;180(4):1367–72. doi: 10.1016/j.juro.2008.06.016 . [PMC free article] [PubMed] [CrossRef[]
19. Schlager TA, Anderson S, Trudell J, Hendley JO. Effect of cranberry juice on bacteriuria in children with neurogenic bladder receiving intermittent catheterizationJ Pediatr. 1999;135(6):698–702. doi: 10.1016/s0022-3476(99)70087-9 . [PubMed] [CrossRef[]
20. Kontiokari T, Sundqvist K, Nuutinen M, Pokka T, Koskela M, Uhari M. Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in womenBMJ. 2001;322(7302):1571. doi: 10.1136/bmj.322.7302.1571. [PMC free article] [PubMed] [CrossRef[]
21. McGuinness SD, Krone R, Metz LM. A Double-Blind, Randomized, Placebo-Controlled Trial of Cranberry Supplements in Multiple SclerosisJournal of Neuroscience Nursing. 2002;34(1):4–7. 01376517-200202000-00002. []
22. Waites KB, Canupp KC, Armstrong S, DeVivo MJ. Effect of cranberry extract on bacteriuria and pyuria in persons with neurogenic bladder secondary to spinal cord injuryJ Spinal Cord Med. 2004;27(1):35–40. doi: 10.1080/10790268.2004.11753728 . [PubMed] [CrossRef[]
23. McMurdo MET, Bissett LY, Price RJG, Phillips G, Crombie IK. Does ingestion of cranberry juice reduce symptomatic urinary tract infections in older people in hospital? A double-blind, placebo-controlled trialAge Ageing. 2005;34(3):256–61. . [PubMed[]
24. Hess MJ, Hess PE, Sullivan MR, Nee M, Yalla SV. Evaluation of cranberry tablets for the prevention of urinary tract infections in spinal cord injured patients with neurogenic bladderSpinal Cord. 2008;46(9):622–6. doi: 10.1038/sc.2008.25 . [PubMed] [CrossRef[]
25. Ferrara P, Romaniello L, Vitelli O, Gatto A, Serva M, Cataldi L. Cranberry juice for the prevention of recurrent urinary tract infections: a randomized controlled trial in childrenScand J Urol Nephrol. 2009;43(5):369–72. doi: 10.3109/00365590902936698 . [PubMed] [CrossRef[]
26. Barbosa-Cesnik C, Brown MB, Buxton M, Zhang L, DeBusscher J, Foxman B. Cranberry juice fails to prevent recurrent urinary tract infection: results from a randomized placebo-controlled trialClin Infect Dis. 2011;52(1):23–30. . [PMC free article] [PubMed[]
27. Sengupta K, Alluri KV, Golakoti T, Gottumukkala GV, Raavi J, Kotchrlakota L, et al. A Randomized, Double Blind, Controlled, Dose Dependent Clinical Trial to Evaluate the Efficacy of a Proanthocyanidin Standardized Whole Cranberry (Vaccinium macrocarpon) Powder on Infections of the Urinary TractCurrent Bioactive Compounds. 2011;7:39–46. []
28. Salo J, Uhari M, Helminen M, Korppi M, Nieminen T, Pokka T, et al. Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trialClin Infect Dis. 2012;54(3):340–6. . [PubMed[]
29. Takahashi S, Hamasuna R, Yasuda M, Arakawa S, Tanaka K, Ishikawa K, et al. A randomized clinical trial to evaluate the preventive effect of cranberry juice (UR65) for patients with recurrent urinary tract infectionJ Infect Chemother. 2013;19(1):112–7. doi: 10.1007/s10156-012-0467-7 . [PubMed] [CrossRef[]
30. Foxman B, Cronenwett AEW, Spino C, Berger MB, Morgan DM. Cranberry juice capsules and urinary tract infection after surgery: results of a randomized trialAm J Obstet Gynecol. 2015;213(2):194.e1-.e8. doi: 10.1016/j.ajog.2015.04.003. [PMC free article] [PubMed] [CrossRef[]
31. Vostalova J, Vidlar A, Simanek V, Galandakova A, Kosina P, Vacek J, et al. Are High Proanthocyanidins Key to Cranberry Efficacy in the Prevention of Recurrent Urinary Tract Infection? Phytother Res. 2015;29(10):1559–67. doi: 10.1002/ptr.5427 . [PubMed] [CrossRef[]
32. Maki KC, Kaspar KL, Khoo C, Derrig LH, Schild AL, Gupta K. Consumption of a cranberry juice beverage lowered the number of clinical urinary tract infection episodes in women with a recent history of urinary tract infectionAm J Clin Nutr. 2016;103(6):1434–42. . [PubMed[]
33. Wan K-S, Liu C-K, Lee W-K, Ko M-C, Huang C-S. Cranberries for Preventing Recurrent Urinary Tract Infections in Uncircumcised BoysAltern Ther Health Med. 2016;22(6):20–3. . [PubMed[]
34. Temiz Z, Cavdar I. The effects of training and the use of cranberry capsule in preventing urinary tract infections after urostomyComplement Ther Clin Pract. 2018;31:111–7. doi: 10.1016/j.ctcp.2018.01.017 . [PubMed] [CrossRef[]
35. Mooren ES, Liefers WJ, de Leeuw JW. Cranberries after pelvic floor surgery for urinary tract infection prophylaxis: A randomized controlled trialNeurourol Urodyn. 2020;39(5):1543–9. doi: 10.1002/nau.24391 . [PubMed] [CrossRef[]
36. Wang C-H, Fang C-C, Chen N-C, Liu SS-H, Yu P-H, Wu T-Y, et al. Cranberry-containing products for prevention of urinary tract infections in susceptible populations: a systematic review and meta-analysis of randomized controlled trialsArch Intern Med. 2012;172(13):988–96. doi: 10.1001/archinternmed.2012.3004 . [PubMed] [CrossRef[]
37. Blumberg JB, Camesano TA, Cassidy A, Kris-Etherton P, Howell A, Manach C, et al. Cranberries and their bioactive constituents in human healthAdvances in nutrition (Bethesda, Md). 2013;4(6):618–32. . [PMC free article] [PubMed[]
38. Higgins, JPT. Cochrane handbook for systematic reviews of interventions version 5.0. 2: Cochrane handbook for systematic reviews of interventions.
39. Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statementPLoS Med. 2009;6(7):e1000097. doi: 10.1371/journal.pmed.1000097. [PMC free article] [PubMed] [CrossRef[]

Articles from PLOS ONE are provided here courtesy of PLOS

Plaats een reactie ...

Reageer op "Cranberrysap en cranberrysuppletie verminderen aanzienlijk het risico op urineweginfecties bij daarvoor gevoelige mensen blijkt uit grote meta-analyse studie"

Gerelateerde artikelen

Gerelateerde artikelen

Alternatieve therapieën bij >> Algemene artikelen over complementaire >> Ayurvedische kruiden en middelen >> Voorlichtingsfilmpjes over >> Agaricus Blazei Murill een >> Aids - HIV en effect van voeding >> Aldara zalf - Imiquimod, een >> Aloe Vera naast chemo bij >> AMAS test - Anti Maligne Antibody >> Antioxidanten, voeding en >>