15 september 2021: Zie ook dit artikel: https://kanker-actueel.nl/tcm-traditionele-chinese-kruiden-zouden-kunnen-helpen-tegen-de-gevolgen-van-het-corona-virus-zeggen-chinese-onderzoekers.html

Betrouwbare adressen van TCM artsen en acupuncturisten staan hier: 

https://kanker-actueel.nl/adressen-van-betrouwbare-tcm-artsen-en-acupuncturisten.html

Zie ook TCM studies specifiek bij longkanker.


15 september 2021: Bron: PLOS one Published: August 20, 2021

Veel onderzoeken hebben aangetoond dat TCM - Traditionele Chinese Medicijnen (kruiden) in combinatie met een westerse aanpak  bij de behandeling van milde tot matige COVID-19 - coronavirus superieur was aan westerse aanpak alleen. Dit blijkt uit een meta-analyse van 12 gerandomiseerde studies bij totaal 1393 patiënten die besmet waren met het coronavirus - Covid-19.

De kenmerken van de opgenomen RCT's staan vermeld in  (Table 1). In alle opgenomen studies kregen de patiënten in de controlegroep een conventionele westerse behandeling, terwijl patiënten in de behandelingsgroep een combinatiebehandeling van TCM - Traditionele Chinese Medicijnen en conventionele westerse behandeling kregen. De duur van de behandeling varieerde van 5 tot 15 dagen. Van de twaalf RCT's [1526] waren er studies verdeeld over meerdere ziekenhuizen [181922]  en de overige negen waren uitgevoerd in 1 ziekenhuis. 

In deze review werden negen oraal in te nemen TCM kruiden gebruikt: Jinhua Qinggan granule [15], Toujie Quwen granule [1617], Jinyinhua oral liquid [1825], Lianhua Qingwen capsule (granule) [1923], Maxing Xuanfei Jiedu Decoction [20], Lianhua Qingke granule [21], Reyanning mixture [22], Jiawei Dayuan Decoction [24], diammonium glycyrrhizinate [26].

Zie Table 2. https://doi.org/10.1371/journal.pone.0256429.t002

De top 3 gerangschikte Chinese kruiden die het meest waren gebruikt waren kamperfoelie (58,33%) [15192325 forsythia (50,00%) [1517192123]en ephedra (50,00%) [1519212324].

Vier doseringsformuleringen van orale TCM werden opgenomen, waaronder granulaat [1517212324], orale vloeistof [182225], capsule [1926] en afkooksel  [20]. De meest gebruikte doseringsformulering was granule (50,00%) [1517212324]

Een van de belangrijkste verschillen werd gevonden bij het maken van een long CT. Dit is de originele tekst uit het studierapport:

Clinical efficacy.

Lung CT. The evaluation criteria for a lung CT refer to the COVID-19 Guidelines for Imaging Assisted Diagnosis [27]. Lung CT can evaluate the curative effect through the parameters basic absorption, improvement, no change, and aggravation. If the lesion range disappears ≥70%, it indicates basic absorption. If the lesion range disappeared ≥30%, it indicates improvement. If there was no change in the lesion range, it indicates no change. If the extent of the lesion increased by ≥30%, it indicates aggravation. The effectiveness of therapy based on lung CT = (basic absorption cases + improvement cases)/total cases × 100%. Seven trials enrolling 845 patients mentioned lung CT [161924]. A fixed-effects model was used due to no significant heterogeneity (I2 = 8%, P = 0.37). Meta-analysis revealed that combination therapy could significantly improve lung CT [RR = 1.26, 95%CI (1.15, 1.38), P<0.00001] (Fig 3a). Subgroup analysis showed that there was a significant difference between subgroups with 7 days of treatment duration (P = 0.03) and 10 to 14 days of treatment duration (P<0.00001) (Fig 3a).

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Fig 3.

Forest plot of the effects of combination therapy for outcomes of (a) lung CT, (b) clinical cure rate, (c) rate of conversion to severe cases, (d) viral nucleic acid testing.

https://doi.org/10.1371/journal.pone.0256429.g003 

In het orginele studierapport, gepublicerd in PLOS one en peer reviewed, staan veel meer details en grafieken. Klik op de titel van het abstract voor het volledige studierapport:

Published: August 20, 2021

Abstract

Introduction

Coronavirus disease 2019 (COVID-19) has emerged as a global pandemic since its outbreak in Wuhan, China. It is an urgent task to prevent and treat COVID-19 effectively early. In China’s experience combating the COVID-19 pandemic, Chinese herbal medicine (CHM) has played an indispensable role. A large number of epidemiological investigations have shown that mild to moderate COVID-19 accounts for the largest proportion of cases. It is of great importance to treat such COVID-19 cases, which can help control epidemic progression. Many trials have shown that CHM combined with conventional therapy in the treatment of mild to moderate COVID-19 was superior to conventional therapy alone. This review was designed to evaluate the add-on effect of CHM in the treatment of mild to moderate COVID-19.

Methods

Eight electronic databases including PubMed, EMBASE, Cochrane Central Register of Controlled Trials, the Clinical Trials.gov website, China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), Wanfang Database and China Biology Medicine (CBM) were searched from December 2019 to March 2021 without language restrictions. Two reviewers searched and selected studies, and extracted data according to inclusion and exclusion criteria independently. Cochrane Risk of Bias (ROB) tool was used to assess the methodological quality of the included RCTs. Review Manager 5.3.0 software was used for statistical analysis.

Results

Twelve eligible RCTs including 1393 participants were included in this meta-analysis. Our meta-analyses found that lung CT parameters [RR = 1.26, 95% CI (1.15, 1.38), P<0.00001] and the clinical cure rate [RR = 1.26, 95%CI (1.16, 1.38), P<0.00001] of CHM combined with conventional therapy in the treatment of mild to moderate COVID-19 were better than those of conventional therapy. The rate of conversion to severe cases [RR = 0.48, 95%CI (0.32, 0.73), P = 0.0005], TCM symptom score of fever [MD = -0.62, 95%CI (-0.79, -0.45), P<0.00001], cough cases [RR = 1.43, 95%CI (1.16, 1.75), P = 0.0006], TCM symptom score of cough[MD = -1.07, 95%CI (-1.29, -0.85), P<0.00001], TCM symptom score of fatigue[MD = -0.66, 95%CI (-1.05, -0.28), P = 0.0007], and CRP[MD = -5.46, 95%CI (-8.19, -2.72), P<0.0001] of combination therapy was significantly lower than that of conventional therapy. The WBC count was significantly higher than that of conventional therapy[MD = 0.38, 95%CI (0.31, 0.44), P<0.00001]. Our meta-analysis results were robust through sensitivity analysis.

Conclusion

Chinese herbal medicine combined with conventional therapy may be effective and safe in the treatment of mild to moderate COVID-19. More high-quality RCTs are needed in the future.

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