5 januari 2021: Veel informatie over de vaccins en de tijdschema's van vaccineren tegen het coronavirus staan op deze website: https://www.rijksoverheid.nl/onderwerpen/coronavirus-vaccinatie
Zie ook in gerelateerde artikelen.

Zie ook artikel over het Moderna vaccin: 

https://kanker-actueel.nl/vaccin-van-moderna-mrna-1273-geeft-een-effectiviteit-van-94-en-een-half-procent-tegen-covid-19-blijkt-uit-een-tussenevaluatie.html

Zie ook artikel over het Pfizer vaccin: 

https://kanker-actueel.nl/pfizer-vaccin-tegen-het-coronavirus-covid-19-geeft-hoopgevende-tussenresultaten-met-90-procent-effectiviteit-maar-er-zijn-nog-veel-vragen-te-beantwoorden.html

Zie ook eerdere berichtgeving over het AZD1222 vaccin bij ook ouderen in dit artikel: 

https://kanker-actueel.nl/oxford-studie-naar-vaccin-tegen-coronavirus-covid-19-toont-een-robuuste-immuunrespons-bij-ouderen-55-de-groep-met-het-hoogste-risico-op-de-ziekte.html

5 januari 2021: Over de mRNA vaccins heeft , wetenschapsjournalist van de Volkskrant een interessant artikel geschreven. mRNA techniek komt in feite uit de oncologie en heeft al zijn nut bewezen als immuuntherapie bij melanomen bv. Arts-bioloog drs. Engelbert Valstar wees me hierop maar ik had dit artikel al gelezen. Maar voor wie is geïnteresseerd: De grote belofte van de techniek achter de coronavaccins

De eerste coronavaccins, sinds deze week in gebruik, zijn gebaseerd op een sciencefictionachtige techniek waaraan wetenschappers tientallen jaren sleutelden. Nu dat eindelijk is gelukt: wat is er nog meer op komst? Behandelingen tegen kanker, een betere griepprik, medicijnen tegen slopende erfelijke ziektes misschien?>>>>>>>lees verder

23 november 2020: Bron: Astrazeneca

In een persbericht zegt AstraZeneca dat hun vaccin AZD1222 dat wordt ontwikkeld samen met de universiteit van Oxford een effectieve bescherming geeft van tussen de 60 en 90 procent tegen het coronavirus - Covid-19. Gemiddeld kwam 70 procent effectiviteit uit de tussenresultaten samengevoegd en samen geanalyseerd.
De 60 procent werd gehaald met twee volle doses om de vier weken toegediend. De 90 procent werd gezien als vrijwilligers eerst een halve dosis kregen en een maand later een volle dosis eropvolgend. 

Uit het persbericht:

One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart. The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70%. All results were statistically significant (p<=0.0001). 

Van dit Oxford-vaccin is ook door de Nederlandse regering een aantal doses aangekocht. 

Hier het studieprotocol van AZD1222

In The Lancet werd 18 november 2020 ook deze studie met het AZD1222 vaccin gepubliceerd (abstract in dit artikel): Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial

Hier het volledige persbericht dat AstraZeneca vanmorgen uit liet gaan:

AZD1222 vaccine met primary efficacy endpoint in preventing COVID-19

This announcement contains inside information

23 November 2020 07:00 GMT
 

Two different dosing regimens demonstrated efficacy with one showing a better profile

No hospitalisations or severe cases of COVID-19 in participants treated with AZD1222
 

Positive high-level results from an interim analysis of clinical trials of AZD1222 in the UK and Brazil showed the vaccine was highly effective in preventing COVID-19, the primary endpoint, and no hospitalisations or severe cases of the disease were reported in participants receiving the vaccine. There were a total of 131 COVID-19 cases in the interim analysis.

One dosing regimen (n=2,741) showed vaccine efficacy of 90% when AZD1222 was given as a half dose, followed by a full dose at least one month apart, and another dosing regimen (n=8,895) showed 62% efficacy when given as two full doses at least one month apart. The combined analysis from both dosing regimens (n=11,636) resulted in an average efficacy of 70%. All results were statistically significant (p<=0.0001). More data will continue to accumulate and additional analysis will be conducted, refining the efficacy reading and establishing the duration of protection.

An independent Data Safety Monitoring Board determined that the analysis met its primary endpoint showing protection from COVID-19 occurring 14 days or more after receiving two doses of the vaccine. No serious safety events related to the vaccine have been confirmed. AZD1222 was well tolerated across both dosing regimens.

AstraZeneca will now immediately prepare regulatory submission of the data to authorities around the world that have a framework in place for conditional or early approval. The Company will seek an Emergency Use Listing from the World Health Organization for an accelerated pathway to vaccine availability in low-income countries. In parallel, the full analysis of the interim results is being submitted for publication in a peer-reviewed journal.

Professor Andrew Pollard, Chief Investigator of the Oxford Vaccine Trial at Oxford, said: “These  findings  show  that  we  have  an  effective  vaccine  that  will  save  many  lives. Excitingly, we’ve found that one of our dosing regimens may be around 90% effective and if this dosing regime is used, more people could be vaccinated with planned vaccine supply. Today’s announcement is only possible thanks  to  the  many  volunteers  in  our  trial,  and  the  hard  working  and  talented  team  of  researchers based around the world.”

Pascal Soriot, Chief Executive Officer, said: “Today marks an important milestone in our fight against the pandemic. This vaccine’s efficacy and safety confirm that it will be highly effective against COVID-19 and will have an immediate impact on this public health emergency. Furthermore, the vaccine’s simple supply chain and our no-profit pledge and commitment to broad, equitable and timely access means it will be affordable and globally available, supplying hundreds of millions of doses on approval.”

The pooled analysis included data from the COV002 Phase II/III trial in the UK and COV003 Phase III trial in Brazil. Over 23,000 participants are being assessed following two doses of either a half-dose/full-dose regimen or a regimen of two full doses of AZD1222 or a comparator, meningococcal conjugate vaccine called MenACWY or saline. The global trials are evaluating participants aged 18 years or over from diverse racial and geographic groups who are healthy or have stable underlying medical conditions.

Clinical trials are also being conducted in the US, Japan, Russia, South Africa, Kenya and Latin America with planned trials in other European and Asian countries. In total, the Company expects to enrol up to 60,000 participants globally.

The Company is making rapid progress in manufacturing with a capacity of up to 3 billion doses of the vaccine in 2021 on a rolling basis, pending regulatory approval. The vaccine can be stored, transported and handled at normal refrigerated conditions (2-8 degrees Celsius/ 36-46 degrees Fahrenheit) for at least six months and administered within existing healthcare settings.

AstraZeneca continues to engage with governments, multilateral organisations and collaborators around the world to ensure broad and equitable access to the vaccine at no profit for the duration of the pandemic.

COV002

COV002 is a single-blinded, multi-centre, randomised, controlled Phase II/III trial assessing the safety, efficacy and immunogenicity of AZD1222 in 12,390 participants in the UK. Trial participants to date are aged 18 years or over, who are healthy or have medically stable chronic diseases and are at increased risk for being exposed to the SARS-CoV-2 virus. Participants receive one or two intramuscular doses of a half dose (~2.5 x1010 viral particles) or full dose (~5x1010 viral particles) of AZD1222 or comparator, meningococcal vaccine MenACWY. Participants have blood samples drawn and clinical assessments for safety as well as immunogenicity at multiple timepoints up to one year post-vaccination. Suspected cases presenting with compatible symptoms were tested for virological confirmation by COVID-19 PCR. In addition, weekly swabbing are done for detection of infection and assessment of vaccine efficacy against infection.

COV003

COV003 is a single-blinded, multi-centre, randomised, controlled Phase III trial assessing the safety, efficacy, and immunogenicity of AZD1222 in 10,300 participants in Brazil. Trial participants to date are aged 18 years or over, who are healthy or have medically stable chronic diseases and are at increased risk for being exposed to the SARS-CoV-2 virus. Participants are randomised to receive two intramuscular doses of a full dose (~5x1010 viral particles) of AZD1222 or comparator, meningococcal vaccine MenACWY as first dose and a saline placebo as second dose. Participants have blood samples drawn and clinical assessments for safety as well as immunogenicity at multiple timepoints up to one year post-vaccination. Suspected cases presenting with compatible symptoms were tested for virological confirmation by COVID-19 PCR.

AZD1222
AZD1222 was co-invented by the University of Oxford and its spin-out company, Vaccitech. It uses a replication-deficient chimpanzee viral vector based on a weakened version of a common cold virus (adenovirus) that causes infections in chimpanzees and contains the genetic material of the SARS-CoV-2 virus spike protein. After vaccination, the surface spike protein is produced, priming the immune system to attack the SARS-CoV-2 virus if it later infects the body.

AstraZeneca

AstraZeneca (LSE/STO/Nasdaq: AZN) is a global, science-led biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines, primarily for the treatment of diseases in three therapy areas - Oncology, Cardiovascular, Renal & Metabolism, and Respiratory & Immunology. Based in Cambridge, UK, AstraZeneca operates in over 100 countries and its innovative medicines are used by millions of patients worldwide. Please visit astrazeneca.com and follow the Company on Twitter @AstraZeneca.

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